課程概述 （一）1.Genome projects review; 2.Study on disease resistance relevant to autoimmune disease; 3.Current Genomics/Proteomics concepts
（二）Reviews of genetics: 1.Mendelian analysis; 2.Gene and chromosome; 3.Alleles; 4.Dominance and penetrance; 5.Chromosome structure in eukaryotes
（三）Recombination: 1.Recombination (prokaryote and eukaryote); 2.Nature of gene; 3.Manipulation of DNA; 4.Transposable genetic elements
（四）Major histocompatibility complex (MHC): 1.Molecular genetic; 2.Molecular diversity; 3.Polymorphism
（五）T cell receptor (TcR): 1.TcR gene organization; 2.Genetic diversity of TcR; 3.T cell development
（六）1.Immunoglobulin (Ig) gene organization; 2.Genetic diversity of Ig
（七）1.Genetic diseases; 2.Immuno-disorders: Autoimmunity; Allergic disorders
（八）1.Therapy of immuno-disorders and genetic disorders; 2.Application of laboratory animal in immuno-genetic study: Transgenic animal; Recombinant inbred animal
（九）1.Genetic map and physical map; 2.Genetic marker and genotyping; 3.Chromosomal assignment; 4.Linkage analysis; 5.Introduction to quantitative genetics
（十）Paper presentation and discussion
課程目標 使選課學生瞭解免疫現象受遺傳控制、導致免疫異常現象之潛在遺傳相關等機制，及進行更深入研究所必備的概念。